Abstract: Unambiguity in nondeterministic Turing machines is a well-studied concept in structural complexity. It has proved to be useful in characterizing worst-case one-to-one one-way functions, studying closure of #P under polynomial-time computable operations, classifying natural computational problems, and in the context of propositional proof systems. In this talk, we will first review the concept of unambiguity in nondeterministic, alternating, and hierarchical models of computation. Then we will demonstrate the power of unambiguity in these computational models. This talk is based on joint work with Holger Spakowski.