Welcome to the home page of the ISU Laboratory for Nanoscale Self-Assembly. Our research is motivated by the prospect, raised by pioneering work of Seeman and Winfree, of engineering structures that autonomously assemble themselves from molecular components. We are primarily interested in understanding the power and limitations of this "programming of matter". Our work includes the development and analysis of mathematical models of self-assembly, the creation and use of software environments for developing and simulating self-assembly systems, studies of the self-assembly of fractals and other complex structures, reliable methods for reasoning about self-assembly processes, and using riboswitching to reduce intrinsic error rates in molecular implementations of self-assembly.